EDETOX logo

IN VIVO STUDIES FURTHER DETAILS


BACK TO THE MAIN MENU

back to previous page forward to next page

University of Newcastle homepage

In Vivo Study No: 240

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Benzoic Acid0.026.1050.1221Ethyleneglycol/TritonX100 (90:10)HumanOuter Upper Arm120.5Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
24            
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     9  

NOTES

Caucasian Humans were used in this study. They also predicted that 12nmols would be excreted in 4 days and did a parallel study where they measured the amount found in the SC after 0.5h (6.8nmol) and used this to predict how much would have entered the body after 4 days (11.9nmol)

REFERENCE

Racial Differences In The In Vivo Percutaneous Absorption Of Some Organic Compounds: A Comparison Between Black, Caucasian and Asian Subjects (1993) Arch. Dermatol. Res., 284 :456-459