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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 246

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Acetylsalicylic Acid	0.02	9.008	0.18016	Ethyleneglycol/TritonX100 (90:10)	Human	Outer Upper Arm	1	2	0.5	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
24

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					9

NOTES

Caucasian Humans were used in this study. They also predicted that 19.9nmols would be excreted in 4 days and did a parallel study where they measured the amount found in the SC after 0.5h (11.9nmol) and used this to predict how much would have entered the body bafter 4 days (21.2nmol)

REFERENCE

Racial Differences In The In Vivo Percutaneous Absorption Of Some Organic Compounds: A Comparison Between Black, Caucasian and Asian Subjects (1993) Arch. Dermatol. Res., 284 :456-459