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In Vivo Study No: 251

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
4-Aminobenzoic acid0.054.30.0215EthanolHumanVentral Forearm10224Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
16841.56 0.063429.50.00120.56  32915.38.415.3
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     5  

NOTES

the % Absorption was determined by correcting the amount excreted in the urine after a topical dose with the amount excreted in the urine after an intravenous dose in the rhesus monkey.

REFERENCE

Percutaneous Absorption Of Salicylic Acid, Theophylline, 2,4-Dimethylamine, Diethyl Hexyl Phthalic Acid, And p-Aminobenzoic Acid In The Isolated Perfused Porcine Skin Flap Compared To Man In Vivo (1998) Toxicol. Appl. Pharmacol., 151 :159-165