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IN VIVO STUDIES FURTHER DETAILS

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In Vivo Study No: 252

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
DEHP	0.05	3.7	0.0185	Ethanol	Human	Ventral Forearm	10	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
168	5.75		0.0083	4.5	0.00028	0.15			0.00333	1.8	0.5	1.8

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					6

NOTES

the % Absorption was determined by correcting the amount excreted in the urine after a topical dose with the amount excreted in the urine after an intravenous dose in the rhesus monkey.

REFERENCE

Percutaneous Absorption Of Salicylic Acid, Theophylline, 2,4-Dimethylamine, Diethyl Hexyl Phthalic Acid, And p-Aminobenzoic Acid In The Isolated Perfused Porcine Skin Flap Compared To Man In Vivo (1998) Toxicol. Appl. Pharmacol., 151 :159-165