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In Vivo Study No: 254

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Fluazifop-butyl40.50.0025Commercial Emulsifyable ConcentrateHumanBack80028Gas chromatography/Mass Spectroscopy

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
168        0.1597.951.557.95
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     6  

NOTES

The site was washed with distilled water after 8 hours and the volunteers showered after 24h. Both plasma and urine samples were analysed. They calculated the absorbed dose at discrete timepoints by adding the cumulative urinary excretion to the bosy burden. They found that absorption did not occur to any significant extent after 24 hours which is when the volunteers showered.

REFERENCE

The Predictive Accuracy Of In Vitro Measurements For The Dermal Absorption Of A Lipophilic Penetrant (Fluazifop-Butyl) Through Rat And Human Skin (1994) Fundam. Appl. Toxicol., 23 :230-236