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IN VIVO STUDIES FURTHER DETAILS


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In Vivo Study No: 257

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Fluazifop-butyl0.0250.50.0025Commercial Emulsifyable ConcentrateRatDorso-Lumbar5272Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
72        0.0092974.3 74.3
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     18  

NOTES

The % absorption has been calculated by adding together the amount found in the urine and the amount found in the faeces.

REFERENCE

The Predictive Accuracy Of In Vitro Measurements For The Dermal Absorption Of A Lipophilic Penetrant (Fluazifop-Butyl) Through Rat And Human Skin (1994) Fundam. Appl. Toxicol., 23 :230-236