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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 270

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Propoxur	0.3	50	0.15	60% aq. Ethanol	Human	Volar Forearm	100	2	4	HPLC & gas chromatoghraphy

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
24			0.127	84.67					0.56	3.73	2.93	3.73

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

0.127

84.67

0.56

3.73

2.93

3.73

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
1			7.33	0.0101	3	2E-05	2.4

NOTES

the volunteers were males 23-24 years old. The kinetic behaviour of the propoxur was first assessed by an iv study. The percutaneous experiment was conducted 7 days after the iv experiment. % Absorption was calculated by dividing the amount excreted in the urine after the topical dose by the amount excreted in the urine after an iv dose.

REFERENCE

Comparative In Vitro-In Vivo Percutaneous Absorption Of The Pesticide Propoxur (2000) Toxicol. Sci., 58 :15-22