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In Vivo Study No: 272

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Propoxur0.1150.1560% aq. EthanolRatBack1014Radilabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
72  62.241.47  16.811.20.511534.16.134.1
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
20.9  10.53640.001390

NOTES

The application site was occluded with laboratory film. Male Wistar Rats were used. % absorption was calculated by adding together the amounts excreted in the urine and the faeces.The maximal flux was calculated using blood kinetics of intravenously dosed rats.

REFERENCE

Comparative In Vitro-In Vivo Percutaneous Absorption Of The Pesticide Propoxur (2000) Toxicol. Sci., 58 :15-22