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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 272

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Propoxur	0.1	15	0.15	60% aq. Ethanol	Rat	Back	10	1	4	Radilabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
72			62.2	41.47			16.8	11.2	0.5115	34.1	6.1	34.1

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
20.9			1	0.536	4	0.00139	0

NOTES

The application site was occluded with laboratory film. Male Wistar Rats were used. % absorption was calculated by adding together the amounts excreted in the urine and the faeces.The maximal flux was calculated using blood kinetics of intravenously dosed rats.

REFERENCE

Comparative In Vitro-In Vivo Percutaneous Absorption Of The Pesticide Propoxur (2000) Toxicol. Sci., 58 :15-22