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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 274

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Chlordecone	0.1	4.67	0.167	Acetone	Rat	Back	2.8	2	72	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
72							0.000145	0.087	0.0423	9.04	1.1	9.04

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

0.000145

0.087

0.0423

9.04

1.1

9.04

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					3

NOTES

Young Female Fischer 344 Rats were used. Results were given in nmols which I have converted to micrograms and +/- SE which I have converted to SD for this database. The dosing area was protected with a perforated 5ml plastic beaker.

REFERENCE

Percutaneous Absorption And Disposition Of [14C]Chlordecone In Young And Adult Female Rats (1998) Environ. Res, 79 :138-155