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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 281

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Pentachlorophenol	See Notes		0.0007	Hexane:methylene chloride & Soil	Monkey	Abdomen	12	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
336			0.003192	38					0.00205	24.4	6.4	24.4

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

336

0.003192

0.00205

24.4

6.4

24.4

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					4

NOTES

Soil constitutied 26% sand 26% clay 48% silt and 0.9% organic. 40mg/cm2 of soil were added. % absorption was obtained from finding the amount excreted in the urine and correcting it for incomplete excretion by comparison with the amount excreted after an intravenous dose.

REFERENCE

Percutaneous Absorption Of Pentachlorophenol From Soil (1993) Fundam. Appl. Toxicol., 20 :68-71