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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 283

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
2-Butoxyethanol	See Notes	0.00024		Air	Human	Whole Body		2	2	GC with Electron Capture Detection

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
4

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
				1.158	4

NOTES

This study was conducted at normal air temperature and humidity (23oC, 29% rel. humidity) The BE Vapour was generated in an exposure chamber and maintained at 2mmol/m3. the subjects sat in the chamber only wearing shorts and were fitted with a resiratory mask connected to a tank containing pressurised clean air. Immediately after the 2h exposure the subjects took a shower. The average absorption rate was 32 micromols/min. This was calculated as the product of the apparent blood clearance and the AUC of skin exposure. The results from this study were compared to those from an inhalation study.

REFERENCE

Percutaneous Absorption Of 2-Butoxyethanol Vapour In Human Subjects (1991) Br. J. Ind. Med., 48 :788-792