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In Vivo Study No: 289

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Dibutylphthalate0.1105010.5None (Neat)RatBack1024Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
4100.85.783.2779.3  20.4819.51.9951.90.61.9
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
 40   83.8E-05 

NOTES

Sprague~Dawley Rats were used. The application site was protected with a perforated circular plastic cup. % Absorption was calculated by adding together the amounts found in the urine + faeces + carcass + cage wash. The results were given as +/- SEM. I have changed these to SD for the database

REFERENCE

In Vivo And In Vitro Percutaneous Absorption Of [14C]Di-N-Butylphthalate In Rat (2001) Drug Met. Dispos., 29 :843-853