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IN VIVO STUDIES FURTHER DETAILS


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In Vivo Study No: 295

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Disodium Octaborate Tetrahydrate1.81000.2WaterHumanBack900124Radiolabelled (14C) & ICPMS

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
168  113.7663.2    0.21960.1220.1080.122
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
 0.00975   81E-07 

NOTES

The application site was occluded with a white T-shirt. % absorption was calculated by analysing the amount found in the urine.

REFERENCE

In Vivo Percutaneous Absorption Of Boric Acid, Borax, and Disodium Octaborate Tetrahydrate In Humans Compared To In Vitro Absorption In Human Skin From Infinite And Finite Doses (1998) Toxicol. Sci., 45 :42-51