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IN VIVO STUDIES FURTHER DETAILS


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In Vivo Study No: 296

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Diazinon0.050.47040.0056AcetoneRatMid-dorsal4.2224Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
336100.22.970.010444.6  4.7E-050.20.01355.10.9655.1
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     4  

NOTES

Male Sprague-Dawley Rats were used. The dose site was protected from surface rub-off by a foam rubber non-occlusive patch. % Absorption has been calculated from the amount found in the Urine + faeces + tissue.

REFERENCE

In Vitro Dermal Absorption Of Pesticides IV. In Vivo And In Vitro Comparison with the Organophosphorus Insecticide Diazinon In Rat, Guinea Pig, Pig, Human And Tissue-Cultured Skin (1994) Toxicol. Vitro, 8 :1213-1218