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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 3

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Triclopyr	0.9	288	3.55	Garlon 4 Herbicide	Human	Left Forearm	73	2	8	Gas Chromatography

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
84									4.276	1.65		1.65

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

4.276

1.65

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
			12	0.08	6		3

NOTES

Amount of Triclopyr and size of exposure site were dependent on body weight. The volume varied between 0.65-1.10 ml of Garlon 4 equivalent to 5mg Triclopyr per kg. Size of site was 1cm2 per kg. The mean has been used in this database. They also did Oral studies. They measured the amount of the metabolite 3,5,6-TCP excreted in the oral study. This was found to be negligable, from this they concluded that very little Triclopyr is metabolised by man. The % Absorbed dose has been calculated by correcting the amount found in the urine by comparison with the % recovery from the oral dose.

REFERENCE

Oral And Dermal Pharmacokinetics Of Triclopyr In Human Volunteers (1989) Hum. Toxicol., 8 :431-437