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In Vivo Study No: 300

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Fenoxaprop-ethyl0.050.15120.0018Excel 9ECRatBack4.2224Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
264        0.00136184.4618
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     6  

NOTES

The dose area was shaved before application. % Absorption was calculated from the amount excreted in the urine. This was corrected for incomplete recovery by comparison with an intramuscular dose. The dose site was protected with a non-occlusive foam-rubber patch.

REFERENCE

An Automated In Vitro Dermal Absorption Procedure: II. Comparative In Vivo And In Vitro Dermal Absorption Of The Herbicide Fenoxaprop-ethyl (HOE 33171) In Rats (1992) Toxicol. Vitro, 6 :53-59