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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 303

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Fenoxaprop-ethyl	0.05	8.4	0.1	Excel 9EC	Rat	Back	4.2	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
264									0.0865	20.6	4.48	20.6

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

264

0.0865

20.6

4.48

20.6

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					6

NOTES

% Absorption was calculated from the amount excreted in the urine. This was corrected for incomplete recovery by comparison with an intramuscular dose. The dose site was protected with a non-occlusive foam-rubber patch.

REFERENCE

An Automated In Vitro Dermal Absorption Procedure: II. Comparative In Vivo And In Vitro Dermal Absorption Of The Herbicide Fenoxaprop-ethyl (HOE 33171) In Rats (1992) Toxicol. Vitro, 6 :53-59