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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 310

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Arsenic	0.06	0.42	0.0021	Water	Monkey	Abdomen	12	2	24	Radiolabelled (73As)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
168				77.7					0.0005	2	1.2	2

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

168

77.7

0.0005

1.2

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					3

NOTES

The % absorption was calculated from the amount present in the urine. This was corrected for incomplete excretion by comparing with the amount excreted after an intravenous dose.

REFERENCE

In Vivo And In Vitro Percutaneous Absorption And Skin Decontamination Of Arsenic From Water And Soil (1993) Fundam. Appl. Toxicol., 20 :336-340