EDETOX logo

IN VIVO STUDIES FURTHER DETAILS


BACK TO THE MAIN MENU

back to previous page forward to next page

 University of Newcastle homepage

In Vivo Study No: 332

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Parathion0.1 0.004AcetoneRatBack 2 Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
120         98.990.2998.99
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     3  

NOTES

Dublin Male Rats were used. % absorption was calculated by adding the amounts found in the urine, faeces, blood, liver, and carcass. Respiratory products were also collected but amounts were less than 1% of the recovered dose. Results were given +/- SE. I have changed this to SD for the purpose of this database.

REFERENCE

Percutaneous Penetration Of Three Insecticides In Rats: A Comparison Of Two Methods For In Vivo Determination (1983) J. Investig. Dermatol., 80 :291-293