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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 335

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
DDT	0.1		0.004	Acetone	Rat	Back		2		Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
120										93.13	0.03	93.13

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

120

93.13

0.03

93.13

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					3

NOTES

Dublin Male Rats were used. % absorption was calculated by adding the amounts found in the excreta and correcting for incomplete excretion by comparison with a parenteral dose. Results were given +/- SE. I have changed this to SD for the purpose of this database.

REFERENCE

Percutaneous Penetration Of Three Insecticides In Rats: A Comparison Of Two Methods For In Vivo Determination (1983) J. Investig. Dermatol., 80 :291-293