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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 355

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Meperidine	0.1	50	0.5556	70% Ethanol	Rat	Back	9	2	24	Radiolabelled (14C) & Thin Layer Chromatography

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
24									2.705	54.1	6.6	54.1

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

2.705

54.1

6.6

54.1

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					4

NOTES

aMale Wistar Rats were used. The rats weighed 200g and the dosing was given as 25mg/kg. % Absorption was calculated by adding together the amounts excreted in the urine and the faeces.

REFERENCE

Perctaneous Absorption Of 3H-Pethidine In The Rat (1980) Arzneim.-Forsch./Drug Res, 30 :267-270