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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 363

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Propoxur	0.3	50	0.15	60% aq. Ethanol	Human	Forearm	100	2	4	HPLC, fluorescence & GC-MS

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
48

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					3

NOTES

They performed this experiment under increasing humidities. They calculated the % of the potentially absorbed dose excreted as IPP. The "potentially absorbed dose" was defined as the difference between the applied dermal dose and the dislodged dose after an exposure duration of 4h. At a relative humidity of 50% 13% of the potentially absorbed dose was excreted as IPP. At 70% 33% was excreted as IPP and at 90% 63% was excreted.

REFERENCE

The Influence Of Skin Moisture on the Dermal Absorption Of Propoxur in Human Volunteers: A Consideration For Biological Monitoring Practices (1997) Sci. Total Environ., 199 :165-172