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In Vivo Study No: 363

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Propoxur0.3500.1560% aq. EthanolHumanForearm10024HPLC, fluorescence & GC-MS

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
48            
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     3  

NOTES

They performed this experiment under increasing humidities. They calculated the % of the potentially absorbed dose excreted as IPP. The "potentially absorbed dose" was defined as the difference between the applied dermal dose and the dislodged dose after an exposure duration of 4h. At a relative humidity of 50% 13% of the potentially absorbed dose was excreted as IPP. At 70% 33% was excreted as IPP and at 90% 63% was excreted.

REFERENCE

The Influence Of Skin Moisture on the Dermal Absorption Of Propoxur in Human Volunteers: A Consideration For Biological Monitoring Practices (1997) Sci. Total Environ., 199 :165-172