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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 364

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Parathion	0.01		0.004	Acetone	Human	Forearm		2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
120										9.7	5.9	9.7

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

120

9.7

5.9

9.7

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					6

NOTES

The chemical concentration and area of skin exposed varied according to the specific acitivity of the chemical that was applied. The % absorption was calculated from the amount excreted in the urine, corrected for incomplete excretion by comparison with excretion from a iv dose. I have extrapolated back the amount found in the urine from the data given in the paper

REFERENCE

Percutaneous Penetration Of Some Pesticides And Herbicides In Man (1974) Toxicol. Appl. Pharmacol., 28 :126-132