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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 374

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Azodrin	0.01		0.004	Acetone	Human	Forearm		2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
120										14.7	7.1	14.7

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

120

14.7

7.1

14.7

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					6

NOTES

The chemical concentration and area of skin exposed varied according to the specific acitivity of the chemical that was applied. The % absorption was calculated from the amount excreted in the urine, corrected for incomplete excretion by comparison with excretion from a iv dose. I have extrapolated back the amount found in the urine from the data given in the paper/

REFERENCE

Percutaneous Penetration Of Some Pesticides And Herbicides In Man (1974) Toxicol. Appl. Pharmacol., 28 :126-132