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In Vivo Study No: 392

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
BenzoinSee Notes 0.004AcetoneMonkeyAbdomen1124Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
120        0.001742.611.642.6
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     4  

NOTES

The application site was occluded with plastic wrap. 4 female rhesus monkeys were used in this study, the monkeys were restrained in metabolic chairs for the duration of the study, except when the washing procedure was taking place. Between 10 and 20 mcrl were added in each study. The results were given +/- SEM. I have converted these to SD for the purpose of this database. % Absorption was determined by measuring the radioactivity recovered in the urine samples, and then correcting the amount of radioactivity for complete excretion with a correction factor obtained from a parentally administered dose.

REFERENCE

In Vivo Percutaneous Absorption Of Fragrance Ingredients In Rhesus Monkeys And Humans (1990) Food Chem.Toxicol., 28 :369-373