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In Vivo Study No: 409

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Dinoseb0.11.9040.068AcetoneRatBack2.8248Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
4890.40.52      0.116361.118.261.1
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     3  

NOTES

Young (33 day-old) Female Fischer Rats were used. The hair on the backs of the animals was removed with electric clippers prior to the experiment. The treated area was protected with a 5ml perforated plastic beaker. The treated animals were maintaimed in Nalgene metabolism cages for urine and faeces collection.% Absorption was calculated by adding together the amounts recovered in the urine + faeces + carcass. Results were given +/- SEM. I have converted these to SD for the purpose of this database.

REFERENCE

Age-related Percutaneous Penetration Of 2-Sec-Butyl-4,6-Dinitrophenol (Dinoseb) In Rats (192) Fundam. Appl. Toxicol., 19 :258-267