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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 421

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Aroclor 1254	0.01	4.8	0.0048	Mineral Oil	Monkey	Abdomen	10	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
816									0.00998	20.8	8.3	20.8

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

816

0.00998

20.8

8.3

20.8

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					4

NOTES

Adult female rhesus monkeys were used. Monkeys were placed in metabolic chairs for the first 24 hours of the study. Skin absorption was determined by cumulative faecal and urinary excretion following topical absorption, corrected for incomplete excretion by comparing with faecal and urinary excretion after and intravenous dose.

REFERENCE

Percutaneous Absorption And Skin Decontamination Of PCBs: In Vitro Studies With Human Skin And In Vivo Studies In The Rhesus Monkey (1990) J. Toxicol. Environ. Health, 31 :235-246