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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 519

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
2-Ethoxyethanol	0.1	907.2	9.45	None (Neat)	Rat	Dorsal	9.6	1	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
24	83.08	9.39	52.58	57.96	0.24	0.26	0.35	0.39	22.78	25.11	10.55	25.11

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					3

NOTES

A glass protective device containing a charcoal pad was glued over the O-ring to occlude the application site and prevent the loss of volatiles. % Absorption was calculated by adding together the % dose in CO2 + urine + faeces + cage wash + blood + liver + carcass + treatment site. Metabolites were measured, but that was part of a separate study of metabolism not relevant to this database.

REFERENCE

Percutaneous Penetration And Metabolism Of 2-Ethoxyethanol (2002) Toxicol. Appl. Pharmacol., 180 :74-82