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IN VIVO STUDIES FURTHER DETAILS


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In Vivo Study No: 530

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
AHTN0.24.50.170% aq. EthanolRatBack911Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
192.3 0.714679.4  0.08939.920.02662.96 2.96
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     2  

NOTES

Lister-Hooded (pigmented) rats were used. After dosing the application area was occluded with aluminium foil. % absorption was calculated from the amounts recovered in the tissues. Excreta were not measured due to the short duration of the experiment.

REFERENCE

The Systemic Exposure To The Polycyclic Musks, AHTN and HHCB, Under Conditions Of Use As Fragrance Ingredients: Evidence Of Lack Of Complete Absorption From A Skin Reservoir (1999) Toxicol. Lett., 111 :133-142