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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 562

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
cis-1,3-Dichloropropene	Infinite	8.6E-05		Air	Human	Forearm	1277	1	0.75	GC-MS

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
24									0.067

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

0.067

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					5	0.8

NOTES

The volunteer was seated in a clean-air cabin under a slight overpressure in order to avoid inhalatory exposure. The volunteer placed the lower arm which was outside the cabin in to a piece of drainage pipe through which the cis-1,3-dichloropropene vapour was led at a flow of 3l/min. The concentration of cis-1,3-DCP vapour during exposure was 86+/-4mg/m3. it was as though the study was occluded due to the infinite dose. The permeability constant was calculated by dividing the total absorbed amount by the exposed area, exposure duration and exposure concentration. No steady state was reached.

REFERENCE

Dermal Absorption Of Cis-1,3-dichloropropene Vapour: Human Experimental Exposure (1996) Hum. Exp. Toxicol., 15 :396-399