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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 599

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Cinnamyl anthranilate	Not Given		0.004	Acetone	Monkey	Abdomen		1	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
120										39	2.8	39

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

120

2.8

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					4

NOTES

Female rhesus monkeys were used. They do not mention how the occlusion was achieved. The application site was lightly clipped prior to application. The monkeys were restrained in metabolic chairs.The amount absorbed was calculated by finding the amount excreted in the urine and correcting for incomplete excretion by comparison with a parenteral dose administered in separate studies. Results were given +/- SEM. I have converted this to SD for this database.

REFERENCE

Comparison of Percutaneous Absorption Of Fragrances By Humans And Monkeys (1985) Food Chem.Toxicol., 23 :111-114