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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 678

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Acetylsalicylic Acid	0.02	9.008	0.18016	ethyleneglycol:triton X-100 (90:10)	Human	Forehead	1	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
24									0.00196	1.089	0.102	1.089

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

0.00196

1.089

0.102

1.089

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					6

NOTES

Male Caucasian volunteers were used in this study. The treated area was delimited by an open circular cell that was fixed with silicon glue. The % Absorption was determined from the amount excreted in the urine and was not corrected.

REFERENCE

In Vivo Percutaneous Penetration Of Some Organic Compounds Related To Anatomic Site In Humans: Predictive Assessment By The Stripping Method (1987) J. Pharm. Sci., 76 :451-454