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IN VIVO STUDIES FURTHER DETAILS


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In Vivo Study No: 74

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Acetylsalicylic AcidNot Given 0.03603Aq. EthanolRatBack120.5Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
96      0.0001530.4250.00123.350.353.35
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     6  

NOTES

Sprague-Dawley hairless Rats were used. Amount added was given as 0.2micromol/cm2. % Absorption is gathered from urine + faeces + sacrificed body including the epidermis & dermis of the application site.

REFERENCE

An Original Predictive Method For In Vivo Percutaneous Absorption Studies (1987) J. Soc. Cosmet. Chem., 38 :397-417