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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 784

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Hydrocortisone	Not Given		0.004	Acetone	Human	Ventral Forearm		2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
120										0.67	0.58	0.67

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

120

0.67

0.58

0.67

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					8

NOTES

65-75 year old volunteers took part in this study. The subjects were all in good health, non-smokers and absent of any obvious skin disease. Percutaneous Absorption was quantified by the amount of the substance excreted in the urine over 5 days, corrected for incomplete absorption by a parenteral correction factor.

REFERENCE

Percutaneous Absorption In The Aged (1986) Dermatologic Clinics, 4 :455-465