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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 796

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Acetyl ethyl tetramethyl tetralin	Not Given			Petrolatum	Rat	Back	2	2	120	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
120										18.9		18.9

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

120

18.9

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)

NOTES

Female-Osborne Mendel Rats 3-6 months old were used. A nylon ring was glued to the back with cyanoacrylate adhesive. The rats were partially restrained with rubber tubing collars. Absorption was estimated by summing the amount excreted in the urine and faeces. Some experimental detail was obtained from ref no 101

REFERENCE

Methods For In Vitro Percutaneous Absorption Studies III: Hydrophobic Compounds (1984) J. Pharm. Sci., 73 :1255-1258