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IN VIVO STUDIES FURTHER DETAILS


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In Vivo Study No: 804

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Anthracene0.0710.160.0093Hexane:Acetone (1:7)RatDorsal1.232144Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
144        0.0059852.31.552.3
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     4  

NOTES

Female Sprague-Dawley Rats were used. A nylon cell was attached to the skin with cyanoacrylate and epoxy adhesives. The concentration was given as ABOUT 0.2mg/ml, however this figure does not fit in with the other figures given. So I have changed it to 0.16 as this was the only figure given as an approximate. % Absorption is calculated from the amount recovered in the urine, faeces and tissues of the rat.

REFERENCE

Percutaneous Absorption Of Anthracene In The Rat: Comparison Of In Vivo And In Vitro Results (1986) Toxicol. Ind. Health, 2 :79-84