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In Vivo Study No: 805

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Salicylic acidNot Given 3dimethylisosorbide + 2-propanolRatFlank5.08224Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
24  1.2281.2281.07711.7377 77
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     5  

NOTES

Female Sprague Dawley Rats were used. The application sites were not occluded but a self-adhesive foam pad, supported by a teflon ring was secured around each site. 2sites each of 2.54cm2 were used. The % absorbed is approximate as the actual amount was not stated in the paper and was read off a graph.

REFERENCE

In Vivo Skin Penetration of Salicylic Compounds in Hairless Rats (2002) Eur. J. Pharm. Sci., 17 :95-104