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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 829

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Salicylic acid	Not Given		0.004	acetone	Monkey	abdomen		2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
168										59	32	59

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

168

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					4

NOTES

4 female rhesus monkeys were used. The application site was lightly clipped before application and was washed after 24h. Urine was collected for 7 days and the data was corrected for incomplete excretion by reference with an iv dose

REFERENCE

In Vivo Percutaneous Absorption of Chemicals: A Multiple Dose Study in Rhesus Monkeys (1990) Food Chem.Toxicol., 28 :129-132