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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 852

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Fenitrothion	0.1	0.026	0.00062	Acetone	Rat	Midlumbosacral	4.2	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
168									0.0022	84	12	84

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

168

0.0022

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					5

NOTES

Male Sprague-Dawley Rats were used. Non-occlusive foam rubber frames covered on top with gauze were used to protect the dose area. After 24 hours the patches were removed the dose areas were washed with radiac soap. Results were corrected for incomplete excretion by comparison with a parentally administered dose. I have worked backwards to find the amount actually excreted in the urine.

REFERENCE

Percutaneous Absorption of the Insecticides Fenitrothion and Aminocarb in Rats and Monkeys (0) J. Toxicol. Environ. Health, 20 :209-218