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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 867

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Paraquat	0.05	12.6	0.009	Water	Human	leg	70	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
120									0.0018	0.29	0.02	0.29

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

120

0.0018

0.29

0.02

0.29

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					6

NOTES

the % absorbed was corrected for incomplete excretion by comparison with the amount excreted after a parentally administered dose in Rhesus Monkeys. In the monkey 58.6% of the parentally administered dose was excreted in the urine

REFERENCE

In Vivo Percutaneous Absorption of Paraquat from Hand, Leg, and Forearm of Humans (1984) J. Toxicol. Environ. Health, 14 :759-762