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IN VIVO STUDIES FURTHER DETAILS


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In Vivo Study No: 87

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Acetylsalicylic AcidNot Given 0.18016Aq. EthanolRatBack126Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
96      0.0004360.240.01498.2651.3998.265
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     5  

NOTES

Sprague-Dawleyhairless Rats were used. Amount added was given as 1micromol/cm2. % Absorption is gathered from urine + faeces + sacrificed body including the epidermis & dermis of the application site.

REFERENCE

An Original Predictive Method For In Vivo Percutaneous Absorption Studies (1987) J. Soc. Cosmet. Chem., 38 :397-417