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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 871

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Acetochlor	0.04	10.75	0.043	Water	Monkey	abdomen	10	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
168									0.0744	17.3	5.9	17.3

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

168

0.0744

17.3

5.9

17.3

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
	0.3	0.1	1		4

NOTES

Female Rhesus Monkeys were used. The monkeys were placed in specially designed metabolic chairs for the first 24 hours and then the application site was washed with 50% soap and water beofre the monkes were transferred to metabolic cages. The % absorption was calculated by comparing the amount excreted in the urine and the faeces with that excreted after an iv dose.

REFERENCE

In Vivo Percutaneous Absorption of Acetochlor in the Rhesus Monkey: Dose-Response and Exposure Risk Assessment (1996) Food Chem.Toxicol., 34 :979-983