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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 873

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Alachlor	0.005	23	0.046	aq. LASSO (1:20) v/v	Monkey	abdomen	2.5	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
168			0.08441	73.4					0.0204	17.7	3.3	17.7

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

168

0.08441

73.4

0.0204

17.7

3.3

17.7

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					4

NOTES

Female Rhesus Monkeys were used. The dosing site was covered with a non-occlusive cover made of two aluminium eye patches with multiple holes sandwiching a piece of gortex fabric. After 24 hours the application site was washed with an ivory soap and water solution. % absorption was calculated from the amount excreted in the urine + faeces.

REFERENCE

In Vivo Percutaneous Absorption and Skin Decontamination of Alachlor in Rhesus Monkey (1992) J. Toxicol. Environ. Health, 36 :1-12