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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 880

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Parathion	Not Given		0.004	acetone	Human	Hand dorsum		2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
120										20.994	8.097	20.994

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

120

20.994

8.097

20.994

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					6

NOTES

% absorption was calculated from the amount recovered in the urine, corrected for incomplete excretion by comparison with an intravenous dose. Data was given for many time points in the experiment, however only the final absorbed amount has been entered into the database.

REFERENCE

Regional Variation in Percutaneous Penetration in Man (1971) Arch. Environ. Health, 23 :208-211