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Chemical Name:
All Chemicals
1,6 Hexanediol diglycidyl ether
11a-hydroxyprogesterone
17a-Hydroxyprogesterone
1-Dodecyl glycidyl ether
1-Methoxypropan-2-ol
2-(2-Butoxyethoxy)ethanol
2-(2-Ethoxyethoxy)ethanol
2(2-Methoxyethoxy)ethanol
2,2',4,4',5,5' Hexachlorobiphenyl
2,3-Butanediol
2,4 Dimethylamine
2,4,6-Trichlorophenol
2,4-Dichlorophenol
2,4-Dichlorophenoxyacetic acid
2-Butanone
2-Butoxyethanol
2-chlorobenzaldehyde
2-Chlorophenol
2-Ethoxyethanol
2-Ethoxyethyl acetate
2-Isopropoxyethanol
2-Methoxyethanol
2-Methoxyethyl acetate
2-Naphthol
2-Naphthylamine
2-Nitro-1,4-Benzenediamine
2-Nitro-4-Phenylenediamine
2-Phenoxyethanol
2-phenylphenol
3,4-Xylenol
3-Nitrophenol
4-Acetamidophenol
4-Amino-2-nitrophenol
4-Aminobenzoic acid
4-aminophenol
4-Bromophenol
4-Chlorophenol
4-Cyanophenol
4-Dimethylaminobenzene
4-Ethylphenol
4-Heptyloxyphenol
4-Iodophenol
4-Nitroaniline
4-Nitrophenol
4-Pentyloxyphenol
5a-dihydrotestosterone
5b-dihydrotestosterone
5-Fluorouracil
5-Methoxypsoralen
8-Methoxypsoralen
Abamectin
Acenaphthene
Acephate
Acetochlor
Acetyl ethyl tetramethyl tetralin
Acetylcysteine
Acetylsalicylic Acid
Acitretin
Acyclovir
AHTN
Alachlor
Aldosterone
Aldrin
Aluminium
Aluminium chlorohydrate
Alupent
Aminocarb
Amobarbitone
Androstenedione
Aniline
Anthracene
Aroclor 1242
Aroclor 1254
Arsenic
Ascorbic Acid
Atrazine
Atropine
Azodrin
Barbitone
Benomyl
Benzamide
Benzene
Benzo(a)anthracene
Benzo[a]pyrene
Benzocaine
Benzoic Acid
Benzoin
Benzophenone
Benzyl Acetate
Benzyl Alcohol
Benzyl Benzoate
Benzyl nicotinate
Beta-Estradiol
Betamethasone 17-valearate
Bisphenol A diglycidyl ether
Borax
Boric Acid
Butachlor
Butanoic Acid
Butobarbital
Butoxyethyl Triclopyr
Butyl 4-hydroxybenzoate
Butyl nicotinate
Butyl salicylate
Caffeine
Capsaicin
Captan
Captopril
Carbaryl
Carbofuran
Catechol
Chloramphenicol
Chlordecone
Chlorocresol
Chlorothalonil
Chloroxylenol
Chlorpheniramine
Chlorpyrifos
Chlorpyrifos Methyl
Chromium
Chrysene
Cinnamic acid
Cinnamyl alcohol
Cinnamyl anthranilate
cis-1,3-Dichloropropene
cis-Permethrin
Clotrimazole
Codeine
Colchicine
Cortexolone
Corticosterone
Cortisone
Coumarin
Cypermethrin
DDT
Decabromodiphenyl Oxide
Decane
DEHP
Deoxycorticosterone
DEP
Dexamethasone
DFP
DHEA
Diazinon
dibutyl squarate
Dibutylphthalate
Diclofenac
Dieldrin
Dienochlor
Diethanolamine
Diethyl Malonate
diethyl squarate
Diethylamine salicylate
Diethylcarbamazine
DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE
Digitoxin
Dimethoate
Dimethyl Phthalate
Dimethylarsenic acid
Dimethylethylamine
Dimethylformamide
Dimethylnitrosamine
Diniconazole
Dinitrochlorobenzene
Dinoseb
Dipropylene glycol methyl ether
Diquat
Disodium Octaborate Tetrahydrate
Disulfoton
DMP
Dodecane
Dodecyl decaethoxylate
Dodecyl monoethoxylate
DSMA
Ephedrine
Epikote YX4000
EPTC
Erioglaucine
Estriol
Estrone
Ethanol
Ethion
Ethyl 4-hydroxybenzoate
Ethyl Benzene
Ethyl ether
Ethyl nicotinate
Etorphine
Etretinate
Fenazaquin
Fenitrothion
Fenoxaprop-ethyl
Fentanyl
Fenvalerate
Fluazifop-butyl
Fluocinolone Acetonide
Fluocinonide
Fluorene
Fluroxypyr Methylheptyl Ester
Flutamide
Folpet
Fomesafen Sodium
Fumaric Acid
Glucose
Glufosinate-Ammonium
Glycerol
Glycerol Trioleate
Glyphosate
Griseofulvin
Guthion
Haloprogin
Heptanoic acid
Hexachlorobenzene
Hexachlorophene
Hexanoic acid
HHCB
Hippuric Acid
Hydrocortisone
Hydrocortisone Acetate
Hydrogen Cyanamide
Hydromorphone
Hydroquinone
Ibuprofen
Indomethacin
Iodochlorhydroxyquin
Iprodione
Isofenphos
Isoquinoline
Ketoprofen
Laurocapram
Lidocaine
Lindane
Linoleic Acid
Lorazepam
Malathion
Mannitol
MbOCA
MCPA
m-Cresol
MDA
Meperidine
Meperidine Hydrochloride
Methamidophos
Methanol
Methiocarb
Methotrexate
Methyl Ethyl Ketoxime
Methyl nicotinate
Methyl-4-hydroxybenzoate
Methylcholanthrene
Methyl-Parathion
Mevinphos
MGK 326
Morphine
MSMA
N,N-Diethyl-m-toluamide
Naphthalene
Naproxen
n-Butanol
n-Decanol
n-Heptanol
n-Hexanol
N-Hexyl Nicotinate
Nicardipine
Nickel
Nicorandil
Nicotinamide
Nicotine
Nicotinic Acid
Nitrobenzene
Nitroglycerine
n-Methyl-2-pyrrolidone
n-Nitrosodiethanolamine
n-Nonanol
n-Octanol
Nonane
Nonivamide
n-Pentanol
N-Phenyl-2-naphthylamine
n-Propanol
n-Propoxyethanol
o-Cresol
o-cresyl glycidyl ether
Octanoic acid
Octyl benzoate
Oleic Acid
Omethoate
o-toluidine
Ouabain
Paclobutrazol
Paraoxon
Paraquat
Parathion
p-Cresol
Pentachlorophenol
Pentanoic acid
Permethrin
Phenanthrene
Phenobarbital
Phenol
Phosmet
Phoxim
Picloram
Pirimicarb
Potassium Thiocyanate
Pregnenolone
Progesterone
Propionic Acid
Propoxur
Propranolol
Propyl 4-hydroxybenzoate
Propylene glycol
Pyrene
Resorcinol
Safrole
Salicylamide
Salicylic acid
Scopolamine
Sodium Benzoate
Sodium Caprate
Sodium Laurate
Sodium Lauryl Sulphate
Sodium laurylbenzenesulphonate
Sodium myristate
Sodium Palmitate
Sodium Salicylate
Sodium stearate
Squaric Acid
Styrene
Sucrose
Sufentanil
T2 Toxin
TCMBT
TDCPP
Terbinafine
Testosterone
Testosterone Acetate
Testosterone Propionate
Tetradecane
Theophylline
Thiobencarb
Thiourea
Thymol
Toluene
trans-Permethrin
Triadimefon
Triamcinolone Acetonide
Trichlorocarbanilide
Trichloroethylene
Trichloromethane
Triclopyr
Triclosan
Tridecane
Trimethylamine
Undecane
Urea
VX
Water
Xylene
Species:
All Species
Dog
Graftskin TM
Guinea pig
Hairless Mouse
Hairless Rat
Human
Human skin grafted mouse
Human skin grafted rat
Marmoset
Minipig
Monkey
Mouse
Pig
Pig skin grafted mouse
Rabbit
Rat
Skinethic TM
Snake
Testskin TM
Vehicle:
Cell Type:
All
flow-through
static
perfused pig ear
Average (Mean) Results for Pyrene with All Species Skin
Lag Time
Kp
Flux
17.41
Page 1 of 1.
4
In Vitro Records Found for Pyrene with All Species Skin, All Cells
Click the Study No. for further experimental detail
Chemical
Study No.
Vehicle
Species
Site
Membrane
Area (cm2)
Cell Type
Exposure Time (h)
Study Length (h)
% Recovery
% Absorbed
s-s-flux (mcrg/cm2/h)
kp (cm/h)
n
Lag Time (h)
Ref.No
Pyrene
1057
Acetone
Monkey
Abdomen
Full Thickness Skin
1.77
Static
72
72
17.41
145
Pyrene
1072
Acetone
Guinea pig
Back
Dermatomed to 0.2mm
0.64
Flow-through
24
24
86
57.4
5
153
Pyrene
1073
Acetone
Guinea pig
Back
Dermatomed to 0.2mm
0.64
Flow-through
24
24
78.3
52.8
5
153
Pyrene
1074
Acetone
Guinea pig
Back
Dermatomed to 0.2mm
0.64
Flow-through
24
24
62
26.9
5
153
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