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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Salicylic acid2090% aq. Propylene glycolHumanAbdomenDermatomed to 0.6mm2.54Static4848   21.92.193 10
Hydrocortisone21Propylene glycolHumanAbdomenDermatomed to 0.6mm2.54Static4848   0.0230.00233 10
Clotrimazole22Propylene glycolHumanAbdomenDermatomed to 0.6mm2.54Static4848   0.020.0023 10
Terbinafine23Propylene glycolHumanAbdomenDermatomed to 0.6mm2.54Static4848   0.010.0013 10
Salicylic acid2490% aq. Propylene glycolPigUnknownDermatomed to 0.6mm2.54Static4848   12.71.273 10
Hydrocortisone25Propylene glycolPigUnknownDermatomed to 0.6mm2.54Static4848   0.0110.00113 10
Clotrimazole26Propylene glycolPigUnknownDermatomed to 0.6mm2.54Static4848   0.020.0023 10
Terbinafine27Propylene glycolPigUnknownDermatomed to 0.6mm2.54Static4848   0.010.0013 10
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