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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Progesterone138340% aq. PEG 400MouseAbdomenFull Thickness Skin Static     2.37  5.49214
11a-hydroxyprogesterone138440% aq. PEG 400MouseAbdomenFull Thickness Skin Static     0.57  6.64214
17a-Hydroxyprogesterone138540% aq. PEG 400MouseAbdomenFull Thickness Skin Static     0.29  4.55214
Corticosterone138640% aq. PEG 400MouseAbdomenFull Thickness Skin Static     0.97  5.5214
Hydrocortisone138740% aq. PEG 400MouseAbdomenFull Thickness Skin Static     0.15  5.5214
Deoxycorticosterone138840% aq. PEG 400MouseAbdomenFull Thickness Skin Static     4.73  3.9214
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