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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Acetylsalicylic Acid1407AcetoneRatDorsalDermatomed to 0.35mm0.32Flow-through2472107.6 16.7  6 219
Testosterone1408AcetoneRatDorsalDermatomed to 0.35mm0.32Flow-through247299.8 35.4  14 219
Salicylic acid1409AcetoneRatDorsalDermatomed to 0.35mm0.32Flow-through2472108 11.4  6 219
Benzoic Acid1410AcetoneRatDorsalDermatomed to 0.35mm0.32Flow-through247289.6 30.5  6 219
Hydrocortisone1411AcetoneRatDorsalDermatomed to 0.35mm0.32Flow-through247291.9 9.8  7 219
Caffeine1412AcetoneRatDorsalDermatomed to 0.35mm0.32Flow-through2472107.3 71.8  6 219
Nicotinic Acid1413AcetoneRatDorsalDermatomed to 0.35mm0.32Flow-through2472101.4 9  7 219
Nicotinamide1414AcetoneRatDorsalDermatomed to 0.35mm0.32Flow-through247298.6 15.3  7 219
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