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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Mannitol124150% aq. DimethylisosorbideHumanAbdomenFull Thickness Skin0.13Flow-through6060   0.936 4 194
Mannitol124250% aq. DimethylisosorbideHumanAbdomenFull Thickness Skin0.13Flow-through6060   0.248 4 194
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