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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Urea1287AcetoneMouseNot GivenFull Thickness Skin2Flow-through6692.3 9.4  3 203
Urea1288AcetoneMouseNot GivenFull Thickness Skin2Flow-through6680.5 12  3 203
Benzoic Acid1289AcetoneMouseNot GivenFull Thickness Skin2Flow-through6681.6 73.6  3 203
Acetylsalicylic Acid1290AcetoneMouseNot GivenFull Thickness Skin2Flow-through55100.9 49.2  3 203
Caffeine1291AcetoneMouseNot GivenFull Thickness Skin2Flow-through6685.2 69.9  3 203
Salicylic acid1292AcetoneMouseNot GivenFull Thickness Skin2Flow-through6691.4 54.1  3 203
Benzoic Acid1293AcetoneMouseNot GivenFull Thickness Skin2Flow-through6678.6 75.5  3 203
Urea1294AcetoneRatNot GivenFull Thickness Skin2Flow-through66103.2 12  3 203
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